Stress Fibers and Fibronectin
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Title: Stress Fibers and Fibronectin
Description: This image has an overwhelming presence of actin or stress fibers of the cells (red). The green protein named fibronectin is stretched out over the cells. The transforming growth factor beta (white) is seen bound to the fibronectin.
The coverslip is stained with lamanin. There are three dyes used. The red channel is the actin channel, the green is fibronectin, and the white is the Transforming Growth Factor Beta.
The research that I am currently working on is how fibronectin assembly induces epithelial to mesenchymal transition (EMT) in mammary epithelial cells via transforming growth-beta signaling. EMT is involved in the progression of breast cancer. TGFB induces EMT and my research focuses on the role of the extracellular matrix protein fibronectin in EMT. The proposed hypothesis is that increasing fibronectin assembly increases the secretion/expression of TGFB. TGFB binds to the receptors on fibronectin.
Roshni Malik, Student, Biomedical Engineering
This image was taken using the 63x oil magnification on the Zeisse microscope. The software used is the Zeisse software.
The coverslip is stained with lamanin. There are three dyes used. The red channel is the actin channel, the green is fibronectin, and the white is the Transforming Growth Factor Beta.
The research that I am currently working on is how fibronectin assembly induces epithelial to mesenchymal transition (EMT) in mammary epithelial cells via transforming growth-beta signaling. EMT is involved in the progression of breast cancer. TGFB induces EMT and my research focuses on the role of the extracellular matrix protein fibronectin in EMT. The proposed hypothesis is that increasing fibronectin assembly increases the secretion/expression of TGFB. TGFB binds to the receptors on fibronectin.
Roshni Malik, Student, Biomedical Engineering
This image was taken using the 63x oil magnification on the Zeisse microscope. The software used is the Zeisse software.
Identifier: ttlg-16
Citation: “Stress Fibers and Fibronectin,” VCU Libraries Gallery, accessed May 4, 2024, https://gallery.library.vcu.edu/items/show/2743.